MDR1 Gene Polymorphism and Phenytoin Pharmacokinetics in Epilepsy
نویسنده
چکیده
29 Epilepsy is considered one of the major public health problems and could have serious psychological and physical consequences, including mental health disorders, traumatic injury and premature death1. Epilepsy is a chronic and disabling neurologic disorder and affects approximately 1% of the population globally, especially in developing countries1,2. Although good prognosis has been seen in most patients with epilepsy, approximately 20% to 30% of patients with epilepsy do not remain seizure free despite the intervention of multiple antiepileptic drugs (AEDs)3,4,5.
منابع مشابه
Association of Acute Lymphoblastic Leukemia and MDR1 Gene Polymorphism in an Ethnic Iranian Population
Background: The frequency of the multi-drug resistance 1 (MDR1) gene C3435T polymorphism differs in various ethnical populations such as Asian, African, and Caucasians populations. A silent C3435T polymorphism in exon 26 of MDR1 has been reported to be associated with a decreased expression of P-gp in TT genotypes carriers compared with CC genotypes carriers. Materials and Methods: To evaluate ...
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متن کاملبررسی فراوانی پلی مورفیسم C3435T ژن MDR1 در بیماران ایرانی مبتلا به کولیت اولسرو
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متن کاملبررسی فراوانی پلی مورفیسم ژنتیکی C3435T ژن MDR1 در یک جمعیت سالم استان مازندران
Background and purpose: The human multidrug resistance gene (MDR1) encodes for P-glycoprotein (P-gp) which is a transmembrane transporter protein acts as an efflux pump for a number of xenobiotics. It plays a protective role for cells against DNA damage caused by toxins and drugs. The wobble C3435T polymorphism at exon 26 has been associated with different expression levels and activities of th...
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